Perioperative management of a child with severe hypertension from a catecholamine secreting neuroblastoma
- Resource Type
- Authors
- Robert C. Shamberger; J. William Sparks; Lisa Diller; Deborah Chirnomas; Christian Seefelder
- Source
- Paediatric anaesthesia. 15(7)
- Subject
- Epinephrine
Phenoxybenzamine
medicine.medical_treatment
Dopamine
Perioperative Care
Norepinephrine (medication)
Pheochromocytoma
Neuroblastoma
Norepinephrine
Catecholamines
Doxazosin
Medicine
Humans
Anesthesia
Enalapril
Antihypertensive Agents
Chemotherapy
business.industry
medicine.disease
Magnetic Resonance Imaging
Kidney Neoplasms
Anesthesiology and Pain Medicine
Child, Preschool
Pediatrics, Perinatology and Child Health
Hypertension
Catecholamine
Female
business
Preanesthetic Medication
medicine.drug
- Language
- ISSN
- 1155-5645
Increased catecholamine secretion from neuroblastomas can occasionally be demonstrated, but severe hypertension is uncommon. We report the perioperative management of a 5 year old child with stage III adrenal neuroblastoma who presented with malignant hypertension and high norepinephrine and dopamine levels. Hypertensive crises occurred during anesthesia for surgical biopsy and during chemotherapy. After blood pressure control using phenoxybenzamine and enalapril, doxazosin was used successfully as the preoperative alpha-adrenergic receptor antagonist for surgical tumor resection.