Risk Factors for Disseminated Coccidioidomycosis, United States
- Resource Type
- Authors
- Steven M. Holland; Beatriz E. Marciano; John N. Galgiani; Camila D. Odio
- Source
- Emerging Infectious Diseases, Vol 23, Iss 2, Pp 311-311 (2017)
Emerging Infectious Diseases
- Subject
- Male
0301 basic medicine
Microbiology (medical)
medicine.medical_specialty
interleukin-12
Epidemiology
coccidioidomycosis
030106 microbiology
lcsh:Medicine
Disseminated coccidioidomycosis
lcsh:Infectious and parasitic diseases
Immunocompromised Host
03 medical and health sciences
Sex Factors
Risk Factors
Sex factors
CME
medicine
Humans
Immunodeficiency
Genetic Predisposition to Disease
Coccidioides
lcsh:RC109-216
race
Disease Resistance
Risk Factors for Disseminated Coccidioidomycosis, United States
immunosuppression
biology
business.industry
IL-12/IFN-γ
lcsh:R
Dispatch
Genomics
interferon
Prognosis
medicine.disease
biology.organism_classification
Dermatology
United States
Infectious Diseases
disseminated coccidioidomycosis
Host-Pathogen Interactions
Immunology
ethnicity
Female
fungi
business
- Language
- English
- ISSN
- 1080-6059
1080-6040
Of 150,000 new coccidioidomycosis infections that occur annually in the United States, ≈1% disseminate; one third of those cases are fatal. Immunocompromised hosts have higher rates of dissemination. We identified 8 patients with disseminated coccidioidomycosis who had defects in the interleukin-12/interferon-γ and STAT3 axes, indicating that these are critical host defense pathways.