Methicillin-resistant Staphylococcus aureus (MRSA) causes a substantial burden of community-acquired and nosocomial infection. Prior colonization with MRSA is a recognized risk factor for MRSA infection. The study aimed to assess the prevalence of and risk factors for MRSA colonization at admission to surgical, medical and orthopaedic wards of Teaching Hospital, Karapitiya, Sri Lanka. From September 2016 to March 2017, consecutive patients admitted to orthopaedic wards and every fifth patient admitted to medical and general surgical wards were enrolled. A nasal swab was collected from the anterior nares within 24 hours of admission and tested using standard microbiologic procedures. Clinical and demographic data were collected. A total of 502 patients were enrolled, including 152 medical, 201 general surgical, and 149 orthopaedic patients. The median age was 45 years (range 3- 85 years) and 58% of patients were male. At admission, 31 (6.2%) were colonized with MRSA. Colonization prevalence was higher in orthopaedic (18, 12.1%) compared to medical (6, 4.0%) and general surgical (7, 3.5%) patients, p=0.002. Patients colonized with MRSA on admission were more likely to be children