Microparticulated systems based on chitosan and poly(vinyl alcohol) with potential ophthalmic applications
- Resource Type
- Authors
- Marcel Popa; Jean-François Chailan; Bernard Fache; Anca Niculina Cadinoiu; Catalina Anisoara Peptu
- Source
- Journal of Microencapsulation
Journal of Microencapsulation, Taylor & Francis, 2015, 32 (4), pp.381-389. ⟨10.3109/02652048.2015.1035682⟩
- Subject
- Male
Vinyl alcohol
Materials science
Pharmaceutical Science
Ionic bonding
Bioengineering
Muscarinic Agonists
Chitosan
Mice
chemistry.chemical_compound
Colloid and Surface Chemistry
Materials Testing
Polymer chemistry
medicine
Animals
Humans
Particle Size
Physical and Theoretical Chemistry
ComputingMilieux_MISCELLANEOUS
Sustained release drug
Organic Chemistry
Pilocarpine
technology, industry, and agriculture
[CHIM.MATE]Chemical Sciences/Material chemistry
Hydrogen-Ion Concentration
Biocompatible material
3. Good health
Drug Liberation
[CHIM.POLY]Chemical Sciences/Polymers
chemistry
Chemical engineering
Covalent bond
Delayed-Action Preparations
Polyvinyl Alcohol
Emulsion
Ophthalmic Solutions
Swelling
medicine.symptom
- Language
- ISSN
- 1464-5246
0265-2048
Spherical microparticles for encapsulation of drugs for the treatment of diseases, with a diameter ranging between 2 and 4 µm, were obtained by double crosslinking (ionic and covalent) of chitosan and poly(vinyl alcohol) blend in a water-in-oil emulsion. Microparticles characterisation was carried out in terms of structural, morphological and swelling properties in aqueous media. The presence of chitosan in particles composition confers them a pH-sensitive character. Toxicity and hemocompatibility tests prove the biocompatible character of microparticles. The pilocarpine loading capacity is high as well as the release efficiency which increases up to 72 and 82% after 6 h. The obtained results recommend the microparticles as sustained release drug carriers for the treatment of eye diseases.