Stereoselective synthesis of ring C-hexasubstituted trianglamines
- Resource Type
- Authors
- Andrea Gualandi; Helen Stoeckli-Evans; Diego Savoia
- Source
- Subject
- N-ALKYLATION
Chemistry
Stereochemistry
Organic Chemistry
Enantioselective synthesis
Ring (chemistry)
Trianglimine
Biochemistry
Stereocenter
Catalysis
PROCHIRAL KETONES
ASYMMETRIC HENRY REACTION
Reagent
HYDROSILYLATION
Stereoselectivity
COMPLEXES
Physical and Theoretical Chemistry
CHIRAL PERAZAMACROCYCLES SYNTHESIS
MACROCYCLIC LIGANDS
- Language
- English
The addition of organolithium reagents to the trianglimine derived from (R,R)-1,2-diaminocyclohexane and terephthalaldehyde gave the corresponding trianglamine with complete stereocontrol and the R configuration of all six newly formed stereocenters. The structure of the hexaphenyl-substituted macrocycle was determined by X-ray crystallographic study. The new trianglamines were tested as ligands in enantioselective catalytic reactions.