Molecularly imprinted polymers-based electrochemical DNA biosensor for the determination of BRCA-1 amplified by SiO
- Resource Type
- Authors
- Min, You; Shuai, Yang; Wanxin, Tang; Fan, Zhang; Pingang, He
- Source
- Biosensorsbioelectronics. 112
- Subject
- Molecular Imprinting
BRCA1 Protein
Limit of Detection
Humans
Breast Neoplasms
Female
Graphite
Biosensing Techniques
DNA, Neoplasm
Electrochemical Techniques
Gold
Silicon Dioxide
- Language
- ISSN
- 1873-4235
A novel electrochemical DNA (E-DNA) biosensing strategy was designed and used for the detection of breast cancer susceptibility gene (BRCA-1). The biosensor was based on gold nanoparticles-reduced graphene oxide (AuNPs-GO) modified glass carbon electrode (GCE) covered with the layer of molecularly imprinted polymers (MIPs) synthesized with rhodamine B (RhB) as template, methacrylic acid (MAA) as the monomer, and Nafion as additive. The signal amplification tracing tag SiO