Design and parallel synthesis of piperidine libraries targeting the nociceptin (N/OFQ) receptor
- Resource Type
- Authors
- Kenneth J. Valenzano; Zhengming Chen; Wendy S. Miller; Shen Shan
- Source
- Bioorganic & Medicinal Chemistry Letters. 13:3247-3252
- Subject
- Stereochemistry
Chemistry
Narcotic Antagonists
Organic Chemistry
Clinical Biochemistry
NOP
Pharmaceutical Science
Biochemistry
Combinatorial chemistry
Nociceptin Receptor
chemistry.chemical_compound
Nociceptin receptor
Piperidines
Drug Design
Receptors, Opioid
Drug Discovery
Combinatorial Chemistry Techniques
Molecular Medicine
Piperidine
Pharmacophore
Receptor
Molecular Biology
- Language
- ISSN
- 0960-894X
Based on literature structures, we proposed a pharmacophore for NOP receptor ligands and used it as a guide for the design of a focused piperidine library and an optimization library. Potent NOP receptor agonists and antagonists were obtained from these libraries as well as a few potent, mu selective agonists.