Magnetic covalent‐organic frameworks‐based extraction followed by UHPLC‐MS/MS for determination and pharmacokinetic study of trace angoroside C in rat plasma after oral administration of Xuanbo Shuangsheng Granule
- Resource Type
- Authors
- Yiqing Cao; Jinglin Zhu; Yang Li; Yulin Qin; Taomin Huang; Yan Li
- Source
- Journal of Separation Science. 45:3556-3566
- Subject
- Coumaric Acids
Magnetic Phenomena
Solid Phase Extraction
Administration, Oral
Filtration and Separation
Rats
Analytical Chemistry
Pharmaceutical Preparations
Tandem Mass Spectrometry
Animals
Trisaccharides
Chromatography, High Pressure Liquid
Metal-Organic Frameworks
Schiff Bases
Drugs, Chinese Herbal
- Language
- ISSN
- 1615-9314
1615-9306
The composition of the traditional Chinese medicine compound preparation is complex, while the content of each active ingredient is extremely low, which brings difficulties to the plasma concentration detection. In this study, the magnetic covalent-organic frameworks were synthesized by a simple one-step Schiff base reaction and applied for the specific extraction of trace angoroside C in rat plasma prior to ultra-high-performance liquid chromatography-tandem mass spectrometry detection. The synthesized magnetic covalent-organic frameworks have high magnetic responsiveness (35.67 emu·g