Inhibitory effects of aspirin and indomethacin on the biosynthesis of PGE2 and PGF2α
- Resource Type
- Authors
- Marc Julius; A. Douglas Bender; Joseph W. Horodniak; J.E. Zarembo
- Source
- Biochemical and Biophysical Research Communications. 57:539-545
- Subject
- Aspirin
Biophysics
Prostaglandin
Cell Biology
Pharmacology
Inhibitory postsynaptic potential
Biochemistry
chemistry.chemical_compound
Seminal vesicle
medicine.anatomical_structure
Biosynthesis
chemistry
Statistical analyses
medicine
lipids (amino acids, peptides, and proteins)
Molecular Biology
Inhibitory effect
medicine.drug
- Language
- ISSN
- 0006-291X
A gas-liquid chromatography system has been used to study the effects of indomethacin and aspirin on the biosynthesis of PGE2 and PGF2α by the prostaglandin synthetase system of bovine seminal vesicle. Both compounds were found to inhibit the production of PGE2 and PGF2α. However, based on statistical analyses, the inhibitory effect of indomethacin was found to be non-selective while aspirin produced statistically significant preferential inhibition of PGE2 over PGF2α.