On the hydrolytic stability of unsymmetric platinum(iv) anticancer prodrugs containing axial halogens
- Resource Type
- Authors
- Qiyuan Zhou; Wai Kit Tang; Shu Chen; Zoufeng Xu; Guangyu Zhu; Chi-Kit Siu
- Source
- Inorganic Chemistry Frontiers. 8:3794-3802
- Subject
- Inorganic Chemistry
Hydrolysis
chemistry
Reducing agent
Ligand
Trans effect
Halogen
chemistry.chemical_element
Anticancer prodrugs
Platinum
Combinatorial chemistry
- Language
- ISSN
- 2052-1553
The longstanding notion that Pt(IV) complexes are inert under physiological conditions where there are limited reducing agents is facing a great challenge. Herein, we systematically investigated the hydrolytic stability of a wide range of unsymmetric Pt(IV) anticancer prodrugs built upon clinical Pt(II) drugs. The detailed structure–stability relationship shows that the hydrolytic stability of one certain axial ligand in Pt(IV) complexes can be dramatically affected by the other five ligands; both the coordination environment of equatorial ligands and the “trans influence” from one axial ligand affect the hydrolytic stability of the counter axial ligand, and the more electronegative axial ligand faces the higher possibility to detach. Inspiringly, this newly discovered structure–stability relationship has been successfully applied to improve the hydrolytic stability of Pt(IV) complexes that contain axial dichloroacetato ligands. Our discovery represents a significant advancement in the theory of the chemical inertness of Pt(IV) complexes toward ligand exchange reactions and provides a practical guide for the future design of Pt(IV) anticancer prodrugs.