Real-time photoacoustic and ultrasonic dual-modality imaging system for early gastric cancer: Phantom and ex vivo studies
- Resource Type
- Authors
- Zhifang Li; Jianyong Cai; Hui Li; Zuoran Li; Huaqin Wui; Yongping Lin
- Source
- Optics Communications. 426:519-525
- Subject
- Materials science
business.industry
Photoacoustic imaging in biomedicine
01 natural sciences
Atomic and Molecular Physics, and Optics
Imaging phantom
Electronic, Optical and Magnetic Materials
Early Gastric Cancer
010309 optics
03 medical and health sciences
0302 clinical medicine
Transducer
Optics
030220 oncology & carcinogenesis
0103 physical sciences
Dual modality
Ultrasonic sensor
Electrical and Electronic Engineering
Physical and Theoretical Chemistry
business
Image resolution
Ex vivo
Biomedical engineering
- Language
- ISSN
- 0030-4018
Photoacoustic (PA) and ultrasonic (US) imaging are promising techniques for imaging biological tissue and diagnosing internal organs. This paper presents a real-time PA and US dual-modality imaging system for early gastric cancer (EGC) based on a clinical US transducer. It has the advantage that only the PA excitation is inside the body but the US imaging system is outside the body, which makes the system less invasive for EGC detection and will be a potential tool for clinical use. The first experiments produced real-time PA images of blood vessel phantoms. Cross-sectional 2D PA images and reconstructed 3D PA images of the blood vessel phantoms demonstrate the system can clearly identity tissue structure. The experiments show that the system has a high axial spatial resolution but a relatively low lateral spatial resolution. The second experiments combining US and PA imaging, an artificial slightly elevated tumor and three artificial superficial flat tumors embedded inside the pig stomach mucosa ex vivo, demonstrate that the system is able to detect EGC accurately.