STUDIES ON CORTICOSTERONE C-20 REDUCTION IN THE MOUSE
- Resource Type
- Authors
- A. F. Burton; Ruth Krehbiel; Marvin Darrach
- Source
- Canadian Journal of Biochemistry and Physiology. 40:1797-1810
- Subject
- chemistry.chemical_classification
medicine.medical_specialty
chemistry.chemical_compound
medicine.anatomical_structure
Endocrinology
Enzyme
chemistry
Corticosterone
Internal medicine
Cell
Kinetics
medicine
General Medicine
- Language
- ISSN
- 0576-5544
The intravenous injection of corticosterone in the mouse was followed by liver assays for corticosterone and 20α- and 20β-dihydrocorticosterone. The 20α-epimer proved to be the more abundant product. Corticosterone 20α-reductase activity of mouse liver was shown to be associated with the dialyzed soluble fraction of the cell which served as an enzyme preparation for a study of certain properties of corticosterone 20α-reductase and the kinetics of the forward and reverse reactions.