How to facilitate early diagnosis of CNS involvement in malignant lymphoma
- Resource Type
- Authors
- Michael Glantz; Jose Alberto Orfao; Magali Le Garff-Tavernier; Francisco Javier Penalver; Carole Soussain; Javier Pardo-Moreno; Mathias Schmid; Gabriele Buda; Myrto Costopoulos; Agnieszka Korfel; Hind Bennani; Martha Nowosielski
- Source
- Expert Review of Hematology. 9:1081-1091
- Subject
- Pathology
medicine.medical_specialty
Diagnostic methods
Lymphoma
Cytodiagnosis
Secondary CNS lymphoma
cerebrospinal fluid cytomorphology
response criteria
CNS Involvement
Disease
Multimodal Imaging
Sensitivity and Specificity
Central Nervous System Neoplasms
Diagnosis, Differential
Malignant lymphoma
Outcome Assessment (Health Care)
03 medical and health sciences
0302 clinical medicine
Cerebrospinal fluid
Diagnosis
Outcome Assessment, Health Care
Humans
Medicine
cerebrospinal fluid flow cytometry
meningeal
neuroaxis MRI
novel markers
parenchymal
Biomarkers
Early Detection of Cancer
Phenotype
Reproducibility of Results
Hematology
Response criteria
business.industry
medicine.disease
030220 oncology & carcinogenesis
Differential
Csf biomarkers
business
030217 neurology & neurosurgery
- Language
- ISSN
- 1747-4094
1747-4086
Introduction: Making the diagnosis of secondary CNS involvement in lymphoma can be difficult due to unspecific signs and symptoms, limited accessibility of brain/myelon parenchyma and low sensitivity and/or specifity of imaging and cerebrospinal fluid (CSF) examination currently available.Areas covered: MRI of the total neuroaxis followed by CSF cytomorphology and flow cytometry are methods of choice when CNS lymphoma (CNSL) is suspected. To reduce the numerous pitfalls of these examinations several aspects should be considered. New CSF biomarkers might be of potential diagnostic value. Attempts to standardize response criteria are presented.Expert commentary: Diagnosing CNSL remains challenging. Until diagnostic methods combining high sensitivity with high specifity are routinely introduced, high level of awareness and optimal utilization of examinations currently available are needed to early diagnose this potentially devastating disease.