Heparin-induced tau filaments are structurally heterogeneous and differ from Alzheimer's disease filaments
- Resource Type
- Authors
- Neil A. Eschmann; Michael Vigers; Andrew K. Goring; Yann Fichou; Songi Han
- Source
- Chemical communications (Cambridge, England). 54(36)
- Subject
- Amyloid
Pyrrolidines
Thiosulfonic Acids
Heparin metabolism
macromolecular substances
Plasma protein binding
Protein aggregation
Protein Aggregation, Pathological
Catalysis
Protein structure
Alzheimer Disease
mental disorders
Materials Chemistry
medicine
Humans
Amino Acid Sequence
Protein Structure, Quaternary
Molecular Structure
Chemistry
Heparin
Metals and Alloys
Membrane Proteins
General Chemistry
Peptide Fragments
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Biophysics
Spin Labels
Protein Multimerization
medicine.drug
Protein Binding
- Language
- ISSN
- 1364-548X
Alzheimer's disease (AD) is characterized by the presence of tau filaments in the brain whose structure was recently solved. The formation of AD filaments is routinely modeled in vitro by mixing tau with heparin. This study shows that heparin-induced tau filaments are markedly different from the AD filaments and are highly heterogeneous.