Cephradine Intercalated Mg-Al Layered Double Hydroxide
- Resource Type
- Authors
- Nashid Kaisher Riyadh; Ashaduzzaman; Sayed Md. Shamsuddin; Nusrat Mustary
- Source
- International Letters of Chemistry, Physics and Astronomy. 69:1-9
- Subject
- 010407 polymers
Materials science
Scanning electron microscope
Intercalation (chemistry)
Inorganic chemistry
02 engineering and technology
021001 nanoscience & nanotechnology
Alkali metal
01 natural sciences
0104 chemical sciences
Amorphous solid
chemistry.chemical_compound
chemistry
Attenuated total reflection
Hydroxide
Molecule
0210 nano-technology
Cephradine
Nuclear chemistry
- Language
- ISSN
- 2299-3843
Engineered advanced functional materials are promising candidates for biotechnology and biomedical science. Mg-Al layered double hydroxide (LDH), anionic or hydrotalcite-like clays consist of positively charged layers and exchangeable anions along with water molecules in the interlayer space were synthesized from homogeneous solution of MgCl2 and AlCl3 by urea induced co-precipitation method. A pharmaceutically important drug, cephradine was intercalated with synthesized LDH in alkali media (pH 10) by in-situ technique. Characterizations of the products were carried out using Attenuated Total Reflectance Infra-red (ATR-IR), Energy Dispersive X-ray (EDX) and X-ray Diffraction (XRD) spectroscopy. Scanning electron morphological images envisaged a distinct crystalline and amorphous phases of Mg-Al LDH before and after modification with cephradine. Intercalation of bioactive molecules with LDH would enhance their stability providing sustained release behavior in physiological environment.