Successfully treated bronchopulmonary oxalosis caused by Aspergillus tubingensis in a non-neutropenic patient: A case report and review of the literature
- Resource Type
- Authors
- Hirohisa Horinouchi; Hiroki Tateno; Kei Sakamoto; Isano Hase; Jin Kagatani; Fumio Maitani; Katsuhiko Kamei; Shuichi Yoshida; Shoji Suzuki
- Source
- Journal of Infection and Chemotherapy. 28:299-303
- Subject
- Microbiology (medical)
Voriconazole
Hyperoxaluria
medicine.medical_specialty
Aspergillus
Antifungal Agents
biology
business.industry
Mortality rate
Microbial Sensitivity Tests
Disease
Drug susceptibility
Necrotic tissue
biology.organism_classification
Gastroenterology
Non neutropenic
Infectious Diseases
Aspergillus tubingensis
Internal medicine
medicine
Humans
Pharmacology (medical)
business
medicine.drug
- Language
- ISSN
- 1341-321X
Pulmonary oxalosis can be fatal, and Aspergillus tubingensis is commonly resistant to azoles in Japan. We report a case of bronchopulmonary oxalosis caused by A. tubingensis in a non-neutropenic patient who was successfully treated with voriconazole monotherapy. The susceptibility of the isolates to voriconazole and the effective elimination of contagious necrotic tissue by expectoration seemed to be two major factors contributing to the patient's survival. According to the literature review, pulmonary oxalosis is associated with a high mortality rate over a short term. An exploration of detailed information about the genomic characteristics and drug susceptibility of Aspergillus isolates is important for the development of treatment strategies for this life-threatening disease.