Objectives: Secreted Protein Acidic and Rich in Cysteine (SPARC) is a multifunctional glycoprotein, participating in tissue remodeling, morphogenesis and bone mineralization. Furthermore, SPARC controls important mechanisms involved in cancer progression, including angiogenesis regulation. However, in some studies SPARC was found to show tumor suppression while in other a protumorigenic and prometastatic action. In tumor microenvironment some chemokines and their receptors, thanks to their ability to modulate cancer cells migration and proliferation, are involved in the angiogenetic and metastatic process. In this study we compared, in human endometrial cancer tissue (EC) vs normal endometrium counterpart (NE), SPARC with CXCL12, CXCL11, CXCL8, and CXCR7 mRNA expression. Material and Methods: Fresh specimens from 15 patients with EC and corresponding NE were stored at –80°. One mcg of mRNA was reverse-transcribed in cDNA. A Real-Time PCR determined relative cDNA levels of targeted gene mRNA. Results: In EC vs NE, we observed down-regulation of SPARC mRNA in 91% (P