A novel CeO2/TiO2-MoO3 (Ce/TM) catalyst was synthesized by using of Mo as a bulk dopant to boost the NH3-SCR performance of CeO2/TiO2 catalyst. It displayed 100% NO conversion at 200–350 °C under 60,000 mlg−1 h−1 and high tolerance to H2O and SO2 at 250 °C. Characterization results manifested that the doping of Mo not only resulted in more Bronsted acid and Lewis acid sites formed on the Ce/TM surface, but also increased the specific surface area and redox ability of the catalyst, all of which account for the enhanced NH3-SCR activity.