Re-emergence of acute myeloid leukemia in donor cells following allogeneic transplantation in a family with a germline DDX41 mutation
- Resource Type
- Authors
- Gerbrig Berger; Andre B. Mulder; Richard J. Sinke; Birgit Sikkema-Raddatz; Kristin M. Abbott; E. van den Berg; Laura Bungener; Edo Vellenga
- Source
- Leukemia, 31(2), 520-522. Nature Publishing Group
- Subject
- 0301 basic medicine
Cancer Research
Myeloid
Allogeneic transplantation
LINE
Biology
VARIANTS
DEAD-box RNA Helicases
03 medical and health sciences
0302 clinical medicine
Germline mutation
AGE
hemic and lymphatic diseases
medicine
MYELODYSPLASTIC SYNDROMES
Humans
Transplantation, Homologous
Family
Germ-Line Mutation
Myelodysplastic syndromes
Hematopoietic Stem Cell Transplantation
Myeloid leukemia
Hematology
medicine.disease
Tissue Donors
Transplantation
Leukemia, Myeloid, Acute
Haematopoiesis
Leukemia
030104 developmental biology
medicine.anatomical_structure
Oncology
030220 oncology & carcinogenesis
Immunology
- Language
- English
- ISSN
- 0887-6924
Next-generating sequencing (NGS) has helped to reveal the genomic landscape of inherited hematological malignancies. Various genes have recently been identified in families that predispose to increased risk of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). The presentation of the disease varies between the predisposition genes.