Assessment of the immune response to trivalent split influenza vaccine in children with solid tumors
- Resource Type
- Authors
- Aynur Oguz; Semha Berberoglu; Caglar Citak; Ceyda Karadeniz; Neziha Yilmaz; Omer Bektas
- Source
- Subject
- Male
Adolescent
Influenza vaccine
medicine.medical_treatment
Dose-Response Relationship, Immunologic
Antibodies, Viral
Injections, Intramuscular
Immune system
Antigen
Neoplasms
medicine
Humans
Child
Immunization Schedule
Chemotherapy
Hemagglutination assay
business.industry
Vaccination
Significant difference
Antibody titer
Infant
Hematology
Titer
Treatment Outcome
Oncology
Influenza Vaccines
Child, Preschool
Pediatrics, Perinatology and Child Health
Immunology
Female
business
Follow-Up Studies
- Language
- English
Purpose To assess the immune response to influenza vaccine in children with solid tumors receiving chemotherapy or under the influence of chemotherapy. Methods Forty-five children (aged 1–18) with solid tumors on chemotherapy or within 6 months of completion of chemotherapy were included in the study. The children received two doses of intramuscular trivalent split influenza vaccine with 1 month apart in November–December 2003 (children 4 age 0.5 ml). Antibody titer was detected in the pre-vaccination and 4-week post-vaccination sera by hemagglutination inhibition (HI) method. Immune responses were measured as protective, geometric mean titers (GMT), and fourfold rises in HI titers. Results We revealed that the post-vaccination GMT for each of the three antigens in patients with solid tumors has increased significantly (P