Cardiovascular disease (CVD) is one of the leading causes of mortality and morbidity worldwide. Several studies highlighted the association of CVD with hyperuricemia. We searched PubMed, EMBASE, Scopus, and DOAJ with the following keywords, including hyperuricemia and cardiovascular disease, to address these topics: 1) mechanism of hyperuricemia 2) relationship of hyperuricemia with cardiovascular disease 3) Treatment of hyperuricemia