[3+2] Cycloaddition reactions of diethyl (E)-2-fluoromaleate
- Resource Type
- Authors
- Akbar H. Khan; Mehrdad Shadmehr; Rajiv K. Singh; Bethel Asmelash; Timothy B. Patrick
- Source
- Journal of Fluorine Chemistry. 143:109-111
- Subject
- chemistry.chemical_classification
Organic Chemistry
Nuclear magnetic resonance spectroscopy
Biochemistry
Cycloaddition
Nitrone
Inorganic Chemistry
chemistry
Yield (chemistry)
Wittig reaction
Environmental Chemistry
Organic chemistry
Proline
Physical and Theoretical Chemistry
- Language
- ISSN
- 0022-1139
Diethyl E -2-fluoromaleate has been prepared in a pure state in 89% yield by a Horner–Wadsworth–Emmons Wittig procedure. The E configuration was determined by NMR spectroscopy. Diethyl E-2-fluoromaleate undergoes [3+2] cycloadditions with a series of aromatic α-iminoesters and aromatic nitrones. The yields of purified cyclic products ranged from 65 to 80%.