The present study was carried out to investigate the effects of crude ethanol extract of Tapinanthus globiferuson rat kidney. The toxic effects of the extract on rats kidney after 28 days of oral administration were evaluated on serum levels of urea, creatinine, sodium (Na+), potassium (K+), chloride (Cl-) and bicarbonate (HCO3-) while histopathology was evaluated on sections of the kidney. Results from the acute toxicity studies on the extract were found to be greater than 5,000 mg/kg body weight in rats after oral administration. The biochemical analysis of the extract showed significant (p