Controlled release of triamcinolone from an episcleral micro film delivery system for open-globe eye injuries and proliferative vitreoretinopathy
- Resource Type
- Authors
- Yu Shen; Jie Yang; Xiaoli Li; Shaoqun Wu; Lingyun Cheng; Miao Chen; Yuanhui Jin; Chengying Bian
- Source
- Journal of controlled release : official journal of the Controlled Release Society. 333
- Subject
- Drug
Proliferative vitreoretinopathy
medicine.medical_specialty
Triamcinolone acetonide
media_common.quotation_subject
Pharmaceutical Science
02 engineering and technology
Triamcinolone Acetonide
Eye injuries
03 medical and health sciences
Eye Injuries
Tissue engineering
Ophthalmology
medicine
Animals
030304 developmental biology
media_common
0303 health sciences
business.industry
Vitreoretinopathy, Proliferative
021001 nanoscience & nanotechnology
medicine.disease
Controlled release
eye diseases
Sclera
medicine.anatomical_structure
Delayed-Action Preparations
Drug delivery
sense organs
Rabbits
0210 nano-technology
business
medicine.drug
- Language
- ISSN
- 1873-4995
Open globe trauma is the major cause for single eye blindness that stem from subsequent proliferative vitreoretinopathy (PVR). Though biomaterials and tissue engineering have significantly advanced drug delivery and management of human diseases, currently there is no effective drug formulation or device to pharmacologically mitigate PVR formation after open-globe eye trauma. This highlighted the challenge we are facing to bring the technology from bench to bedside. The current study reported an engineered episcleral drug film using biodegradable material, Poly(L-lactide)-co-poly(ɛ-caprolactone), and triamcinolone acetonide (TA) as a model drug. The film can be conveniently sized into any shape to fit the configuration of the eye globe trauma and easily installed onto the ruptured sclera during primary trauma repair surgery. The film allows therapeutic TA to slow release for at least 6 months without toxicity and demonstrated a significant benefit to reduce the odds of developing severe PVR by 5.7 times when compared with a no-drug film control on a rabbit trauma PVR model. Our results suggested this micro episcleral drug film as promising drug delivery carrier for the targeted treatment of various unwanted retinal proliferation diseases.