Made available in DSpace on 2021-06-25T11:07:15Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-11-13 Acetohydroxyacid synthase (AHAS, EC 2.2.1.6), the first enzyme in the branched chain amino acid biosynthesis pathway, is the target for more than 50 commercially available herbicides, and is a promising target for antimicrobial drug discovery. Herein, we have expressed and purified AHAS from Candida auris, a newly identified human invasive fungal pathogen. Thirteen AHAS inhibiting herbicides have Ki values of 100 μM and thus possesses a therapeutic index of >100. These data suggest that targeting AHAS is a viable strategy for treating C. auris infections. School of Chemistry and Molecular Biosciences University of Queensland School of Biomedical Sciences University of Queensland Institute for Molecular Bioscience University of Queensland School of Dentistry São Paulo State University (UNESP) Araraquara, Rua Humaita, 1680 School of Dentistry São Paulo State University (UNESP) Araraquara, Rua Humaita, 1680