Synthesis of 2-Amino-5-acylthiazoles by a Tertiary Amine-Promoted One-Pot Three-Component Cascade Cyclization Using Elemental Sulfur as a Sulfur Source
- Resource Type
- Authors
- Rong-Geng Fu; Hao-Lin Zhang; Wang Yong; Ye-Wei Wang; Fei Xia; Peng Yin; Duo-Wen Yang; Yuan Sun
- Source
- The Journal of organic chemistry. 84(18)
- Subject
- Tertiary amine
010405 organic chemistry
Component (thermodynamics)
Organic Chemistry
chemistry.chemical_element
010402 general chemistry
01 natural sciences
Sulfur
0104 chemical sciences
chemistry.chemical_compound
chemistry
Cascade
Organic chemistry
Cyanamide
- Language
- ISSN
- 1520-6904
A novel one-pot three-component cascade cyclization strategy for the synthesis of 2-amino-5-acylthiazoles using enaminones, cyanamide, and elemental sulfur has been developed. The reported methods have demonstrated good tolerance of various functional groups. Up to 28 2-amino-5-acylthiazole compounds bearing diverse structural differences were successfully synthesized from easily obtained starting materials with moderate to excellent yields. Our method provides an effective way for the access of valuable and potentially bioactive 2-amino-5-acylthiazole derivatives.