Postoperative carcinoembryonic antigen (CEA) levels predict outcomes after resection of colorectal cancer in patients with normal preoperative CEA levels
- Resource Type
- Authors
- Wenqian Zheng; Hongbo Zhu; Yangtao Pan; Haiou Qi; Yiming Lv; Lina Shan; Chiming Zhang; Dengyong Xu
- Source
- Translational Cancer Research
- Subject
- Cancer Research
medicine.medical_specialty
Colorectal cancer
Population
Gastroenterology
Metastasis
Colorectal cancer (CRC)
Carcinoembryonic antigen
Internal medicine
medicine
Radiology, Nuclear Medicine and imaging
Clinical significance
Stage (cooking)
carcinoembryonic antigen (CEA)
education
neoplasms
education.field_of_study
biology
business.industry
postoperative follow up
Cancer
medicine.disease
digestive system diseases
Oncology
Tumor progression
biology.protein
Original Article
prognosis
business
- Language
- ISSN
- 2219-6803
Background Carcinoembryonic antigen (CEA) is a cancer biomarker used in colorectal cancer (CRC) for tumor screening and outcome prediction. However it is still lack of sensitivity and specificity in general population. The present study aimed to investigate the clinical significance of CEA in patients with normal preoperative CEA levels. Methods Ninety-four patients were included who received surgery and developed an elevated CEA level postoperatively. They were divided into group A1 and A2 according to the peak CEA level (whether more than 10 ng/mL); group B1 and B2 according to CEA variation (whether reached a normal level at least once). The association between postoperative CEA and overall survival (OS), and disease-free survival (DFS) were analyzed using Kaplan-Meier method and Cox’s proportional hazards regression model. Results The median follow-up time was 38 months. Patients in Group A2 and Group B2 had greater opportunities for recurrence and metastasis (P