Currently, whole uterus and bilateral tubal resection and oophorectomy is the main treatment of cervical mullerian adenosarcoma. However, young patients generally wish to retain reproductive function. The clinical data of a patient with cervical mullerian adenosarcoma, who underwent fertility preservation surgery were collected. A 13-year-old girl with abnormal vaginal bleeding and a 1.0 cm flocculent echogenicity in the lower part of the uterine cavity to the cervical canal and a cervical mass of about 61 mm×37 mm was found in the pelvic MRI. After initial diagnosis of dysfunctional uterine bleeding in adolescence and cervical blood clot, the patient was treated with artificial cycle treatment, but her symptoms did not improve. Then she was transferred to the Third Xiangya Hospital of Central South University for uninjured virgin membrane hysteroscopy and cervical mass electrotomy, but a few pedicles remained after the operation, and the pathology suggested a cervical mullerian adenosarcoma. Because the patient was young and had not yet given birth, she was treated with primary IAP regimen of chemotherapy and subcutaneously injected with gonadotropin-releasing hormone analogue (GNRH-A) once every 28 days (6 times in total) to protect the ovarian function. After the chemotherapy, she was treated with uninjured virgin membrane hysteroscopy and pedicle electrotomy of cervical mullerian adenosarcoma. After the operation, she received chemotherapy with IAP regimen for 5 times. After discharge, she was treated with megestrol 200 mg per day for 3 years. During 5 years of regular follow-up, no abnormality was seen. Cervical mullerian adenosarcoma in non-sexual women is easily misdiagnosed as ovulation dysfunction abnormal uterine bleeding. The necessity of hysteroscopy should be emphasized, and for patients with low-grade early-stage lesions who wish to retain fertility, local resection could be chosen, but attention is paid to lifelong follow-up to exclude long-term recurrence.目前,子宫颈腺肉瘤的治疗主要为全子宫及双侧输卵管和卵巢切除术。然而,年轻患者一般希望保留生育功能。本研究报道1例子宫颈腺肉瘤行保留生育功能手术患者的临床资料。患者13岁,临床表现为异常阴道流血。盆腔MRI示:宫腔下段至宫颈管内1.0 cm絮状回声,宫颈管肿块约61 mm×37 mm。外院初诊考虑青春期功能失调性子宫出血、宫颈管血凝块,予以人工周期治疗,患者症状无改善。转中南大学湘雅三医院行无损伤处女膜宫腔镜检查术+宫颈肿块电切术,术后有少许蒂部残留,病理检查结果提示子宫颈腺肉瘤。因患者年幼,尚未生育,予以1次IAP方案(异环磷酰胺+盐酸表柔比星+顺铂)化学治疗(以下简称化疗)及皮下注射促性腺激素释放激素激动剂(每28 d 1次,共6次)以保护卵巢功能。化疗后再次行无损伤处女膜宫腔镜检查术+宫颈腺肉瘤蒂部电切术,术后再予5次IAP方案化疗。出院后,予以甲地孕酮(200 mg,每日1次)连续治疗3年,定期随访5年,未见异常。无性生活女性子宫颈腺肉瘤尤其易被误诊为排卵障碍性异常子宫出血,应强调宫腔镜检查术的必要性。对于希望保留生育能力的低级别早期病变患者,可选择局部切除,但须终身随访以排除远期复发。.