[Research progress of abnormal phosphorylation of microtubule-associated tau protein and of the targeted inhibition of the phosphorylation]
- Resource Type
- Authors
- Futao, Zhou; Shuangrong, Chen; Xuechuan, Sun
- Source
- Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi. 29(4)
- Subject
- Glycogen Synthase Kinase 3
Alzheimer Disease
Humans
Neurodegenerative Diseases
tau Proteins
Phosphorylation
Protein Kinases
Phosphoric Monoester Hydrolases
- Language
- ISSN
- 1001-5515
Progressive dementia is described as the first and most prominent symptom of Alzheimer's disease (AD), and hyperphosphorylation of microtubule associated Tau protein (MAPT) plays a key role in neurodegeneration and neuronal dysfunction in AD and other neurodegenerative diseases. This paper reviews several protein kinases and phosphatases which can phosphorylate/dephosphorylate Tau protein, and evaluates a therapeutic strategy based on targeted inhibition of Tau kinases and activation of Tau phosphatases.