Early Process Development of an Irreversible Epidermal Growth Factor Receptor (EGFR) T790 M Inhibitor
- Resource Type
- Authors
- Yong Tao; J. Christopher McWilliams; Wiglesworth Kristin; Barbara J. Sitter; Nandell F. Keene
- Source
- Organic Process Research & Development. 23:382-388
- Subject
- integumentary system
biology
010405 organic chemistry
Chemistry
Negishi coupling
Process development
Organic Chemistry
010402 general chemistry
01 natural sciences
0104 chemical sciences
Ammonium hydroxide
chemistry.chemical_compound
Biochemistry
Cleave
biology.protein
Epidermal growth factor receptor
Physical and Theoretical Chemistry
- Language
- ISSN
- 1520-586X
1083-6160
The original synthesis of the irreversible epidermal growth factor receptor (EGFR) T790 M inhibitor 1 was enabled by successful application of ammonium hydroxide to cleanly cleave the N-hydroxymeth...