Urine Drug Screening (UDS) guidelines were initially developed by the government for the purpose of fulfilling employment requisites [1,2]. However, UDS have been utilized by some clinicians to facilitate treatment outcomes in specialized populations such as patients suffering from pain and addictive disorders [3-5]. Recently, there has been a debate on the clinical utility of UDS in improving mental health endpoints in all psychiatric subjects [1]. An emerging body of evidence from different lines of research positively supports the application of UDS in psychiatric practice [4]. However, the relative lack of personalization and general disregard for the patient’s ongoing clinical condition renders the traditional 5-substance panel ill-equipped. More specifically, this conventional panel fails to address issues that pertain to compliance, adherence or drug diversion. In line with this, it has been further reported that drug diversion losses alone may amount to approximately $73 billion per year, which is a peril for health payers [6,7]. These new findings have increased the awareness of psychiatrists and have motivated them to expand the use of drug screens in accordance with evidence-based practices. Proactive initiatives may decrease patient mortality as well as associated social and economic burden on society at large.