The effect of ranitidine on the plasma clearance and hepatic extraction of indocyanine green in patients with chronic liver disease
- Resource Type
- Authors
- T. O. K. Osuafor; R. P. Walt; A. A. Dunk; A. K. Burroughs; S. Mackie; R. Dick; S. Sherlock; W. J. Jenkins
- Source
- British Journal of Clinical Pharmacology. 16:117-120
- Subject
- Adult
Indocyanine Green
Liver Cirrhosis
medicine.medical_specialty
Adolescent
genetic structures
Hemodynamics
Blood Pressure
Ranitidine
Chronic liver disease
Gastroenterology
chemistry.chemical_compound
Liver Function Tests
Internal medicine
Blood plasma
Humans
Medicine
Pharmacology (medical)
Aged
Pharmacology
medicine.diagnostic_test
business.industry
Liver Diseases
Blood flow
Middle Aged
medicine.disease
eye diseases
body regions
Blood pressure
Histamine H2 Antagonists
Liver
chemistry
Anesthesia
Chronic Disease
business
Liver function tests
Indocyanine green
Half-Life
Research Article
medicine.drug
- Language
- ISSN
- 0306-5251
Since hepatic clearance of ICG is reduced by H2-receptor antagonists in normal subjects, it has been suggested that they reduce liver blood flow. We have studied the effect of intravenous ranitidine on ICG clearance in twelve patients with chronic liver disease. Wedged and free hepatic venous pressure were measured before and after intravenous ranitidine in nine of the patients, and the hepatic extraction of ICG was determined in six patients. ICG clearance fell by 22 +/- 11% (s.e. mean) 60 min after ranitidine. In patients in whom ICG clearance fell after intravenous ranitidine the hepatic extraction of ICG was also reduced. There was no significant change in the gradient between wedged and free hepatic venous pressure after ranitidine. It is therefore unlikely that ranitidine lowers liver blood flow.