Actions of lectins from the mushroom Tricholoma mongolicum on macrophages, splenocytes and life-span in sarcoma-bearing mice
- Resource Type
- Authors
- H X, Wang; T B, Ng; V E, Ooi; W K, Liu; S T, Chang
- Source
- Anticancer research. 17(1A)
- Subject
- Male
Mice, Inbred BALB C
Basidiomycota
Macrophages
T-Lymphocytes
Antineoplastic Agents
Lymphocyte Activation
Mice, Inbred C57BL
Mice
Lectins
Animals
Mitogens
Sarcoma 180
Nitrites
Spleen
- Language
- ISSN
- 0250-7005
Two lectins isolated from the mushroom Tricholoma mongolicum stimulated the production of nitrite ions by macrophages in normal and tumor-bearing mice. Both lectins exhibited negligible mitogenic activity toward T-cells or splenocytes from normal mice in vitro when compared with Con A. Similarly, T-cells from sarcoma-bearing mice treated with the lectins did not exhibit a mitogenic response different from that of the control. However, T-cells from normal lectin-treated mice demonstrated a reduced mitogenic response when compared with the control. In mice the growth of sarcoma 180 cells in the peritoneal cavity was inhibited and the life-span was prolonged by the two lectins.