FOCAL SEGMENTAL GLOMERULOSCLEROSIS (FSGS) FACTOR REDUCES EXPRESSION OF INDUCIBLE NITRIC OXIDE SYNTHASE (iNOS) AND PRODUCTION OF NITRIC OXIDE (NO) IN RAT MESANGIAL CELLS (RMC) † 1696
- Resource Type
- Authors
- Howard Trachtman; Pravin C. Singhal; Stephen Futterweit; Mukut Sharma; Virginia Savin
- Source
- Pediatric Research. 41:285-285
- Subject
- medicine.medical_specialty
biology
urogenital system
Chemistry
Plasma factor
urologic and male genital diseases
medicine.disease
female genital diseases and pregnancy complications
In vitro
Nitric oxide
Nitric oxide synthase
Transplantation
Extracellular matrix
chemistry.chemical_compound
Focal segmental glomerulosclerosis
Endocrinology
Internal medicine
Pediatrics, Perinatology and Child Health
medicine
biology.protein
Recurrent disease
- Language
- ISSN
- 1530-0447
0031-3998
Nearly 25% of patients with FSGS develop recurrent disease following renal transplantation. A plasma factor has been isolated from these patients which increases glomerular permeability to protein in vitro. NO modulates renal hemodynamics and extracellular matrix production. Therefore, we studied whether the FSGS plasma factor alters NO synthesis by RMC.