High mitochondrial Ca(2+) content increases cancer cell proliferation upon inhibition of mitochondrial permeability transition pore (mPTP)
- Resource Type
- Authors
- Simone Patergnani; Paolo Pinton; Veronica Angela Maria Vitto; Saverio Marchi
- Source
- Subject
- 0301 basic medicine
Mitochondrion
Biology
Transfection
Mitochondrial Membrane Transport Proteins
NO
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Neoplasms
medicine
Humans
Molecular Biology
Letter to the Editor
Cation Transport Proteins
Cell Proliferation
Calcium metabolism
Mitochondrial Permeability Transition Pore
MPTP
Cancer cell proliferation
Calcium
Calcium Channels
Calcium-Binding Proteins
Gene Knockdown Techniques
HeLa Cells
Mitochondria
PC-3 Cells
Cancer
Mitochondrial calcium uniporter
Cell Biology
medicine.disease
Cell biology
030104 developmental biology
chemistry
Mitochondrial permeability transition pore
030220 oncology & carcinogenesis
Developmental Biology
- Language
- English
The Mitochondrial Calcium Uniporter (MCU) complex, the channel responsible for Ca2+ entry inside mitochondria, is involved in a wide range of diseases, including cancer [1]. Although elevated mitoc...