Chemical activation of MEK1 – a redox trigger for evaluating the effects of phosphorylation
- Resource Type
- Authors
- David H. Lee; Toni L. Lamoureaux
- Source
- Chemical Communications. 47:8623
- Subject
- Sulfates
Reducing agent
Chemistry
Kinase
Phosphatase
MAP Kinase Kinase 1
Metals and Alloys
Chemical modification
General Chemistry
Redox
Antibodies
Catalysis
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
Enzyme Activation
Serine
Biochemistry
Reducing Agents
Materials Chemistry
Ceramics and Composites
Phosphorylation
Cysteine
Oxidation-Reduction
- Language
- ISSN
- 1364-548X
1359-7345
An approach to generate mimics of phosphorylated serine proteins chemically through site-specific sulfonation of cysteine is presented. This chemical modification is reversible in the presence of reducing agent and therefore is analogous to the kinase/phosphatase system used in nature.