Activation of T cell death-associated gene 8 attenuates inflammation by negatively regulating the function of inflammatory cells
- Resource Type
- Authors
- Tomiichiro Oda; Yoshiko Onozawa; Tomoaki Komai
- Source
- European Journal of Pharmacology. 654:315-319
- Subject
- Male
Exacerbation
T-Lymphocytes
T cell
Arthritis
Inflammation
Biology
Methylation
Antibodies
Receptors, G-Protein-Coupled
TCIRG1
Gene Knockout Techniques
Mice
medicine
Animals
Hypersensitivity, Delayed
Receptor
Collagen Type II
Pharmacology
T-cell receptor
Serum Albumin, Bovine
medicine.disease
Arthritis, Experimental
Mice, Inbred C57BL
medicine.anatomical_structure
Knockout mouse
Immunology
Cattle
medicine.symptom
- Language
- ISSN
- 0014-2999
T cell death-associated gene 8 (TDAG8) is a G-protein-coupled receptor identified by differential mRNA display during thymocyte apoptosis induced by T cell receptor engagement. To examine the physiological role of an orphan G-protein-coupled receptor TDAG8 in inflammation, we studied various immune-mediated inflammatory disease models using TDAG8-deficient mice. We found that TDAG8-deficient mice showed significant exacerbation of anti-type II collagen antibody-induced arthritis and delayed-type hypersensitivity, and showed a slight exacerbation of collagen-induced arthritis. These results suggest that TDAG8 acts as a negative regulator of inflammation.