The Re-Os isotopic system is applied for the first time to the sulfide ores and the overlying black-shales at the Kure volcanogenic massive sulfide deposit of the Central Pontides, Northern Turkey. The ore samples collected include predominantly pyrite, accompanied by chalcopyrite, sphalerite and other species. Massive ore is almost free of gangues, whereas the stockwork ore includes quartz and calcite gangue. The composition of sphalerite is similar to ancient and modern massive sulfide mineralizations globally. Microthermometric studies from quartz from the stockwork ore has shown two populations of two-phase fluid inclusions with vapor/liquid ratios between 4 to 28%, low to intermediate T-h (161.5-317.0 degrees C) and low salinities (0.9-5 wt.% NaCl equiv.) which are mostly in good agreement with the ranges for volcanogenic massive sulfide mineralizations. These studies also suggest a H2O-CaCl2-KCl-MgCl2 ore-forming fluid system in a shallower subsurface near the seafloor vents. The Re-Os dating of the LLHR sulfides yield a nominal depositional age of upper Toarcian for the massive sulfide mineralization. Two largely different model ages obtained are attributed to other pyrite crystallization events prior to and postdating the main sulfide deposition. Some lower homogenization temperatures (