Suicide is a leading cause of death among females of reproductive age, with a 5.5-7.4% mortality rate between the ages of 15-44 years (National Center for Health Statistics (U.S.), 2022). A 2006 review paper indicated that individuals are more likely to make a suicide attempt the week before the onset of menses and the week of menses onset (Saunders & Hawton, 2006). Albeit comparisons between groups, a post-mortem study of females indicated that 54.46% of females who died by suicide were menstruating at the time of death, compared to the 6.75% of females who died by other causes of death (Dogra et al., 2007). In another study, researchers indicated reproductive females in states of low estrogen and low progesterone (menstrual phase, amenorrhea, and menopause) were more likely to have increased suicide intent, and specifically in an emergency room setting reproductive females were more likely to make an attempt during their menstrual week (Baca-Garcia et al., 2010). A recent paper indicated that 34% of individuals with PMDD have a lifetime history of suicide attempts, indicating a relationship between individuals who experience this predisposition to emotional hormone sensitivity are at risk for a suicide attempt (Eisenlohr-Moul et al., 2022). Despite evidence for large individual differences in emotional hormone sensitivity, there are no studies prospectively exploring whether greater emotional hormone sensitivity is linked to suicide attempt history. Given the cross-sectional data suggesting greater suicide attempt risk in the weeks surrounding menses, the present study aims to examine whether there is a correlation between degree of cyclical mood change (i.e., emotional hormone sensitivity) and previous lifetime suicide attempt (vs. ideation only) in females. If this association is observed, it would suggest that emotional reactivity to the menstrual cycle serves as a risk factor for not only suicidal ideation, but also suicide attempt, and would support further research aimed at identifying the causes of (and potential treatments for) these emotional symptom changes as a method of suicide prevention.