Introduction: 18 FDG Positron Emission Tomography/Computerised Tomography (PET/CT) imaging may be a useful tool to study lung inflammation in Chronic Obstructive Pulmonary Disease (COPD). Method: The aim of this study was to establish the optimum protocol for 18 FDG-PET/CT imaging of lung inflammation in COPD in combination with quantitative CT analysis of emphysema. 20 moderate-to-severe COPD patients underwent dynamic PET imaging combined with blood sampling to determine the localised plasma activity time curve twice, 4 weeks apart. Patlak analysis of the time-activity curves for CT - derived lung lobes allowed us to generate images of slope (influx constant Ki) and intercept (initial volume of distribution). Results: The signal from PET lung imaging was reproducible as corroborated by Bland Altman plotting (fig 1a). Interestingly the rate of uptake of the tracer as a marker of lung inflammation is related to lung density as measured by full inspiratory phase of the CT scanning (p value