Network pharmacology integrated molecular docking demonstrates the therapeutic mode of Panax ginseng against ovarian cancer
- Resource Type
- Authors
- Sun, Xiao-Fei; Singh, Salam Pradeep
- Source
- Tropical Journal of Pharmaceutical Research; Vol. 22 No. 3 (2023); 589-596
- Subject
- Ginseng, Ovarian cancer, Network pharmacology, Docking, Ginsenosides
Pharmaceutical Science
Pharmacology (medical)
- Language
- ISSN
- 1596-9827
1596-5996
Purpose: To investigate the mode of action of the active ingredients of Panax ginseng against ovarian cancer protein targets elucidated using a network pharmacology approach and molecular docking study. Methods: An integrated protein-protein interactions (PPI) network targeting ovarian cancer and P. ginseng was constructed using a network pharmacology approach and molecular docking was carried out for the active constituents of P. ginseng against the target protein of P. ginseng. Results: Ninety-six compounds were used for the molecular docking simulation against five different proteins from a PPI network of proteins linked to ovarian cancer. The protein-ligand interaction showed strong molecular interaction at the active site of the proteins (p < 0.05).Conclusion: Ginsenosides and their derivatives present in P. ginseng successfully inhibit several key enzymes and proteins associated with ovarian cancer, which may act as potential therapeutic targets for the disease.