Additional file 1: Figure S1. Correlation between proportion African genetic ancestry and the likelihood of harboring an uncertain/conflicting BRCA1/2 variant in Hispanic/Latinos. Figure S2. Phenome-wide association study of BRCA1/2 variant-positive vs. variant-negative participants using EHR-derived clinical diagnoses (phecodes). Table S1. International Classification of Diseases (ICD)-9 and − 10 codes used to characterize BRCA1/2 variant-positive individuals. Table S2. Distribution of 1601 BRCA1/2 variants obtained from exome sequence data available from 30,223 adult BioMe Biobank participants, according to ClinVar assertion and variant type. Table S3. BRCA1/2 expected pathogenic variants identified in 30,223 exome sequenced adults from the BioMe Biobank.