Expression Profiles of Mitochondrial Genes in the Frontal Cortex and the Caudate Nucleus of Developing Humans and Mice Selectively Bred for High and Low Fear
- Resource Type
- Authors
- Jennifer L. McGuire; Brandon W. Higgs; Jennifer Coyner; Suad Diglisic; Luke R. Johnson; Robert J. Ursano; David M. Benedek; Kwang H. Choi; Thien Le
- Source
- PLoS ONE
PLoS ONE, Vol 7, Iss 11, p e49183 (2012)
- Subject
- Pathology
Aging
Mouse
Emotions
Caudate nucleus
lcsh:Medicine
NDUFV1
Mitochondrion
Breeding
Social and Behavioral Sciences
Polymerase Chain Reaction
Mice
Adolescent Psychiatry
Gene expression
Psychology
Prefrontal cortex
lcsh:Science
Child
Psychiatry
Child Psychiatry
Multidisciplinary
Gene Expression Regulation, Developmental
Human brain
Genomics
Animal Models
Fear
Middle Aged
Anxiety Disorders
Frontal Lobe
medicine.anatomical_structure
Mental Health
Genes, Mitochondrial
Child, Preschool
Medicine
Monoamine oxidase B
Research Article
Signal Transduction
Adult
medicine.medical_specialty
Adolescent
Biology
Young Adult
Model Organisms
Developmental Neuroscience
Internal medicine
medicine
Animals
Humans
Behavior
Mood Disorders
Gene Expression Profiling
lcsh:R
Infant, Newborn
Infant
Reproducibility of Results
Gene expression profiling
Endocrinology
lcsh:Q
Caudate Nucleus
Genome Expression Analysis
Neuroscience
- Language
- English
- ISSN
- 1932-6203
A growing body of evidence suggests that mitochondrial function may be important in brain development and psychiatric disorders. However, detailed expression profiles of those genes in human brain development and fear-related behavior remain unclear. Using microarray data available from the public domain and the Gene Ontology analysis, we identified the genes and the functional categories associated with chronological age in the prefrontal cortex (PFC) and the caudate nucleus (CN) of psychiatrically normal humans ranging in age from birth to 50 years. Among those, we found that a substantial number of genes in the PFC (115) and the CN (117) are associated with the GO term: mitochondrion (FDR qv