Objective To monitor features of diarrheogenic bacteria causing blood infection, so as to provide evidence for rational use of drugs in patients with cirrhosis of liver. Methods Diarrheogenic pathogens isolated from blood samples in 302 hospital of PLA from 2000 to 2010 were collected, and their components and antimicrobial resistance were analyzed. Blood samples were cultured with automated blood culture instrument (BACT/ALERT3D) and the bacteria of positive samples were identified by automated microorganism identification device (Vitek2). Furthermore, drug sensitivity test was performed by K-B method recommended by CLSI. Results A total of 140 strains of diarrheogenic bacteria were isolated from the blood samples of 140 patients, among them 117 (83.6%) were male, and the largest proportion (55.7%) of them were aged 40-60 years. The isolated diarrheogenic bacteria causing blood infection included the following genera: Aeromonas(75.71%), Salmonella(14.29%), Vibrio(9.29%) and Yersinia(0.71%). The sensitivity of these bacteria to antimicrobial drugs was different. The incidence of bacteria resistant to ampicillin and cefazolin was significantly higher, while that resistant to levofloxacin was significantly lower, and genus Aeromonaswas more resistant than genus Salmonella(P < 0.01). Multiple antimicrobial resistance was found in genus Aeromonasand genus Salmonella. Genus Vibriowas sensitive to most of antimicrobial drugs. Conclusions A variety of diarrheogenic bacteria with different degree of antibiotic resistance can cause blood infection, and much attention and monitoring should be strengthened.