Frequency of Body Weight Loss is an Independent Prognostic Factor of First-Line Treatment Outcomes in Metastatic Colorectal Cancer
- Resource Type
- Authors
- Stjepko Pleština; Borislav Belev; Juraj Prejac; Domina Kekez; Marija Prejac
- Source
- Nutrition and cancer. 74(2)
- Subject
- 0301 basic medicine
Oncology
Cancer Research
medicine.medical_specialty
Prognostic factor
Colorectal cancer
MEDLINE
Medicine (miscellaneous)
03 medical and health sciences
0302 clinical medicine
Text mining
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
Weight Loss
medicine
Humans
Wasting
Body weight loss
Metastatic colorectal cancer
First line
Progression-free survival
Gastrointestinal tract
030109 nutrition & dietetics
Nutrition and Dietetics
business.industry
Cancer
medicine.disease
Prognosis
First line treatment
Treatment Outcome
030220 oncology & carcinogenesis
Colonic Neoplasms
medicine.symptom
business
Colorectal Neoplasms
- Language
- ISSN
- 1532-7914
One of the main features of wasting in cancer is an involuntary weight loss which is most pronounced in gastrointestinal tract tumors and leads to worse clinical outcomes. The aim of this study is to analyze the frequency of body weight loss (FBWL) as an additional prognostic factor in the treatment of patients with metastatic colorectal cancer (mCRC). In this observational, single-center study, data were retrieved for 236 patients treated for mCRC. FBWL was defined as a percent of change in weight divided by weeks of therapy. Patients were stratified into two groups according to the median of FBWL which equaled to the loss of 0.05 %/week. Patients who lost >0.05 %/week (N=116) had shorter progression-free survival (PFS) in the first-line treatment, then the ones who lost