Long-Term Survival Benefit of Coronary Revascularization in Patients Undergoing Stress Myocardial Perfusion Imaging
- Resource Type
- Authors
- Mario Petretta; Alberto Cuocolo; Marco Salvatore; Roberta Assante; Wanda Acampa; Stefania Daniele; Emilia Zampella; Carmela Nappi
- Source
- Circulation journal : official journal of the Japanese Circulation Society. 80(2)
- Subject
- Male
medicine.medical_specialty
medicine.medical_treatment
Ischemia
Coronary Artery Disease
030204 cardiovascular system & hematology
Revascularization
030218 nuclear medicine & medical imaging
03 medical and health sciences
Myocardial perfusion imaging
0302 clinical medicine
Percutaneous Coronary Intervention
Internal medicine
medicine
Humans
cardiovascular diseases
Survival rate
Aged
Ejection fraction
medicine.diagnostic_test
business.industry
Proportional hazards model
Percutaneous coronary intervention
General Medicine
Middle Aged
medicine.disease
Radiography
Survival Rate
Positron-Emission Tomography
Cardiology
Female
Cardiology and Cardiovascular Medicine
business
Perfusion
Magnetic Resonance Angiography
Follow-Up Studies
- Language
- ISSN
- 1347-4820
Background: We assessed during a long-term follow-up the relationship between clinical outcome and coronary revascularization according to stress gated myocardial perfusion single-photon emission computed tomography (MPS) findings in an observational series of patients with suspected or known coronary artery disease (CAD). Methods and Results: The study group comprised 2059 patients. During a median follow-up of 61 months, 184 events occurred (126 cardiac death and 58 nonfatal myocardial infarction). The impact of revascularization during follow-up on event-free survival was evaluated with the extended Cox regression model, adjusting for potential clinical and MPS confounders. Revascularization was treated as a binary non-reversible time-dependent covariate. Predefined interactions tested were: 1) revascularization and summed difference score (SDS); 2) revascularization and post-stress left ventricular (LV) ejection fraction (EF); and 3) SDS and post-stress LVEF. Revascularization had a significant effect on event-free survival (adjusted hazard ratio 0.19; P