Study Abstract: Objective: The objective of this scoping review is to understand the extent and type of evidence in relation to components of nurse-led models of care associated with improved chronic disease outcomes, access, and costs for the U.S. adult population. Introduction: The proportion of Americans with one or more chronic diseases is growing, signaling the need for a paradigm shift to improve health outcomes, access, and costs in the United States. Nurses have a proven track record of leadership in providing effective care across the continuum from prevention to disease management. To date, no published reviews describe the intersection of nursing models of care and key chronic disease-related outcomes in the United States. This review seeks to elucidate components of nurse-led models of care critical to improving chronic disease outcomes. Inclusion Criteria: The review will assess the U.S. adult population at risk or with chronic disease in relation to nurse-led models, programs, and interventions to understand existing knowledge on components of nurse-led models of care. Methods: A search was conducted by a health sciences librarian in Ovid Medline, CINAHL Complete, and Scopus. The study selection process is in accordance with PRISMA guidelines. Sources were reviewed by at least two independent reviewers to determine if they met the inclusion criteria and a preliminary data extraction charting form is presented in accordance with JBI guidelines for a scoping review.