Risk‐stratifying clinicopathologic criteria for ovarian preservation in premenopausal women with early stage low‐risk endometrial cancer
- Resource Type
- Authors
- Gulden Menderes; Lingeng Lu; Levent Mutlu; Christina Tierney; Wafa Khadraoui; Masoud Azodi; Elena Ratner; Sophie H. Chung
- Source
- International Journal of Gynecology & Obstetrics. 150:385-391
- Subject
- Adult
medicine.medical_specialty
Population
Disease
Endometrium
Young Adult
Biopsy
medicine
Humans
Stage (cooking)
education
Neoplasm Staging
Retrospective Studies
Ovarian Neoplasms
education.field_of_study
medicine.diagnostic_test
Obstetrics
business.industry
Endometrial cancer
Obstetrics and Gynecology
General Medicine
Middle Aged
medicine.disease
Occult
Endometrial Neoplasms
medicine.anatomical_structure
Premenopause
Myometrium
Quality of Life
Female
business
Carcinoma, Endometrioid
Fallopian tube
Endometrial biopsy
- Language
- ISSN
- 1879-3479
0020-7292
Objective To establish the rate of occult ovarian micro-metastases in early stage disease and to provide an eligibility framework for providers to consider ovarian preservation in a patient population with presumed early stage disease. Methods A retrospective review from January 2005 to December 2010 identified women with presumed early stage endometrial cancer from a single institutional database. Inclusion criteria included: (1) FIGO grade 1 endometrioid endometrial cancer on endometrial biopsy; or (2) the same pathology as (1) on frozen section specimen with less than 50% myometrial biopsy; and (3) no evidence of metastatic disease on preoperative imaging or visible metastatic disease in the peritoneal cavity. Results Of the 52 patients, 86.5% were diagnosed with stage IA and 11.5% were diagnosed with stage II disease. One patient (1.9%) had microscopic adnexal involvement in a fallopian tube, which upstaged her to stage IIA disease. None of the patients had ovarian involvement. Conclusion Preservation of the ovaries appears to be a safe and viable option for premenopausal women who are diagnosed with presumed early stage endometrioid endometrial cancer. It is believed that ovarian preservation in this select population will provide them with significant health benefits and improve their quality of life.