The thesis of this brief exposition is the absolute and immediate necessity of preserving existing osteological collections. Once lost, they can never be replaced. They are priceless, historically and culturally. Each collection is unique, in content and in scientific value. No one collection is complete, or replicates any other. These collections are separated by space and by time, by geography and by epoch. They preserve our past, as well as our understanding of human variation. They help us to better understand the human condition and contribute to the advancement of many disciplines including: anthropology, medicine, surgery, anatomy, history, and, undeniably, forensic anthropology. In spite of their uniqueness, all osteological collections face similar challenges: cultural norms and sensitivities, funding, space limitations, and competing priorities. This article provides a succinct overview of several private and public collections around the world, the challenges of preservation, and the benefits of their salvation. The skeletal collections described here are but a sample of what is, and of what may be lost. Anything more would require a book. Anything less would be an irreplaceable and tragic loss.