[Similarity system theory to evaluate similarity of chromatographic fingerprints of traditional Chinese medicine]
- Resource Type
- Authors
- Yongsuo, Liu; Qinghua, Meng; Shumin, Jiang; Yuzhu, Hu
- Source
- Se pu = Chinese journal of chromatography. 23(2)
- Subject
- Quality Control
Models, Chemical
Reproducibility of Results
Chemical Fractionation
Medicine, Chinese Traditional
Peptide Mapping
Chromatography, High Pressure Liquid
Drugs, Chinese Herbal
- Language
- ISSN
- 1000-8713
The similarity evaluation of the fingerprints is one of the most important problems in the quality control of the traditional Chinese medicine (TCM). Similarity measures used to evaluate the similarity of the common peaks in the chromatogram of TCM have been discussed. Comparative studies were carried out among correlation coefficient, cosine of the angle and an improved extent similarity method using simulated data and experimental data. Correlation coefficient and cosine of the angle are not sensitive to the differences of the data set. They are still not sensitive to the differences of the data even after normalization. According to the similarity system theory, an improved extent similarity method was proposed. The improved extent similarity is more sensitive to the differences of the data sets than correlation coefficient and cosine of the angle. And the character of the data sets needs not to be changed compared with log-transformation. The improved extent similarity can be used to evaluate the similarity of the chromatographic fingerprints of TCM.